Lithium Carbonate Tablets – Uses, Dose, Side effects
Bipolar depression is treated with immediate-release and sustained-release pills containing lithium carbonate and other lithium salts (mania and depression).
Indications of Lithium:
- It is approved for the treatment of manic episodes and maintenance therapy in patients with a diagnosis of bipolar disorder older than 7 years old.
Off Label Use Lithium in Adults:
- Bipolar depression
- Augmentation of antidepressant effect
- Prevention of episodic and chronic cluster headache.
Lithium dose in adults:
- For appropriate dosing,monitoring of serum concentrations and clinical response (efficacy and toxicity) is necessary.
- Each 5 mL of lithium citrate oral solution contains 8 mEq of lithium ion, equivalent to the amount of lithium in 300 mg of lithium carbonate immediate release capsules/tablets.
- If tolerated, the dosage of lithium may be reduced to a single dose administered before bed.
Lithium dose in the acute and maintenance treatment of Bipolar disorder:
- 600 to 900 mg/day per oral in 2 to 3 divided doses;
- may increase gradually (eg, 300 to 600 mg every 1 to 5 days) based on response and tolerability.
- usual dosage:
- 900 to 1,800 mg/day in 1 to 3 divided doses.
Lithium dose to augment the antidepressant effect of antidepressant:
- Initiate at a low dose (eg, 300 mg per oral once daily or 300 mg twice daily);
- Dependent on response and tolerability, progressively increase.
- usual dosage:
- 600 to 1200 mg daily in divided doses.
Lithium dose in the prevention of episodic or chronic cluster headache as an alternative agent:
- 300 to 900 mg/day per oral in 1 to 3 divided doses;
- may increase gradually in 300 to 600 mg increments every 1 to 7 days based on response and tolerability, doses up to 1.2 g/day have been studied.
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